Mentha Longifolia And Docetaxel Combined In Colorectal Cancer Cells The Effect of Treatment on DNA Repair Mechanism

Abstract

Aim: Colorectal cancer is a common malignancy with high morbidity and mortality rates worldwide. The emerging resistance to current chemotherapeutic agents increases the need for alternative or supportive treatment strategies. In this study, the effect of the combination of Mentha Longifolia extract, a natural plant, and Docetaxel, a chemotherapeutic agent, on DNA repair mechanisms in colorectal cancer cells was investigated.

Method: In the study, the expression levels of ERCC1 (Excision Repair Cross-Complementation Group 1), which plays a critical role in DNA damage repair, and ATR (Ataxia Telangiectasia and Rad3-related) genes, which have important roles in cellular stress response, were evaluated.

Results: The combined treatment of colorectal cancer cells caused significant changes in the expression of DNA repair genes compared to the components administered alone.

Conclusion: These results suggest that the co-administration of Mentha Longifolia with Docetaxel may improve treatment efficacy by targeting DNA repair pathways and thus reduce the development of resistance to chemotherapy. The findings reveal the potential supportive role of plant-based agents in the treatment of colorectal cancer and provide a basis for future clinical trials.